Due to being were-creatures, werewolves can have an effect towards, and in regards to, animals.

In Wolf Moon, Scott McCall, due to being recently Bitten, entered the cats' room of the animal clinic where he worked, and suddenly the cats began snarling and hissing in the manner as if he were an irregular animal intruder.

Later on, when an injured dog was barking and snapping at Scott and Allison Argent out of fright, because of her broken leg. Scott at once stepped forward seeing if he could calm her down. Right after, as if on instinct, his werewolf eyes flashed and the dog immediately became submissive, and Scott wasn't even aware of, nor had any conscious control over, his werewolf status at that point.

When Allison was changing in a separate room of the clinic, Scott saw her take off her top baring her back, to his excitement. The dog looked at Scott, as if she was sensing Scott's libido hormonal change towards Allison. Scott gave the dog a bashful expression saying "What? I didn't see anything."

Through his continued work at the clinic Scott no longer invokes irregular reactions from animal patients, presumably because he understood enough of his wolf status to mask himself from animals.

In Wolf's Bane, Derek was being pursued by two police dogs. He scared them off by roaring them into submission.